| Date | Opponent | Score | Record |
| October 16, 2010 | Wake Forest | W 15-4 | 1 - 0 |
| October 16, 2010 | Florida State | W 15-8 | 2 - 0 |
| October 16, 2010 | North Carolina | W 15-0 | 3 - 0 |
| October 16, 2010 | NC State | W 15-4 | 4 - 0 |
| October 17, 2010 | Duke | W 15-1 | 5 - 0 |
| October 17, 2010 | Virginia Tech | W 16-14 | 6 - 0 |
| October 17, 2010 | Clemson | W 15-7 | 7 - 0 |
| October 17, 2010 | Virginia Tech | W 15-10 | 8 - 0 |
| November 20, 2010 | James Madison | W 15-13 | 9 - 0 |
| November 20, 2010 | Brandies | W 12-8 | 10 - 0 |
| November 20, 2010 | Pittsburgh | L 7-15 | 10 - 1 |
| November 20, 2010 | Tennessee | W 15-3 | 11 - 1 |
| November 21, 2010 | Virginia Tech | L 7-15 | 11 - 2 |
| November 21, 2010 | Dartmouth | L 12-15 | 11 - 3 |
| November 21, 2010 | UCONN | W 15-8 | 12 - 3 |
| November 21, 2010 | Dartmouth | L 11-13 | 12 - 4 |
